Linaclotide
Performance & EndurancePeptide agonist of guanylate cyclase used for irritable bowel syndrome and chronic constipation.
Key Benefits
- ✓Relieves chronic constipation
- ✓Reduces abdominal pain in IBS-C
- ✓Improves bowel function
- ✓Increases intestinal fluid
- ✓Accelerates transit
Dosing Information
Detailed Protocol
Taken orally once daily on empty stomach, at least 30 minutes before first meal. Swallow whole, do not crush or chew. Prescription required.
About Linaclotide
Linaclotide (Linzess) is a synthetic 14-amino acid peptide that activates guanylate cyclase-C on intestinal epithelial cells. This increases intestinal fluid secretion and accelerates transit. FDA-approved for IBS-C and chronic idiopathic constipation.
Research Notes
FDA-approved in 2012 for IBS-C and CIC. Clinical trials show significant improvements in bowel function and abdominal symptoms. First guanylate cyclase-C agonist approved.
Potential Side Effects
- •Diarrhea (common)
- •Abdominal pain
- •Flatulence
- •Bloating
Always consult with a healthcare professional before starting any peptide therapy.