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Exenatide

Metabolic & Weight Management

First GLP-1 agonist derived from Gila monster saliva, used for type 2 diabetes.

Key Benefits

  • ✓Improves blood sugar control
  • ✓Promotes weight loss
  • ✓Reduces A1C
  • ✓Decreases appetite
  • ✓May preserve beta cell function

Dosing Information

Dosage Range
5-10 mcg (2x/day) or 2 mg (weekly)
Frequency
Twice daily or once weekly
Typical Duration
Ongoing

Detailed Protocol

Available as twice-daily injection (Byetta) or once-weekly extended-release (Bydureon). Twice-daily given within 60 minutes before meals. Weekly given any time. Prescription required.

About Exenatide

Exenatide (Byetta, Bydureon) is a synthetic version of exendin-4, a peptide found in Gila monster saliva. It is a GLP-1 receptor agonist that improves glucose control and promotes weight loss. Available as twice-daily or once-weekly formulations.

Research Notes

First GLP-1 agonist approved by FDA in 2005. Derived from lizard venom peptide. Proven efficacy for diabetes and weight loss, though newer agents better tolerated.

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Potential Side Effects

  • •Nausea (very common)
  • •Vomiting
  • •Diarrhea
  • •Headache
  • •Injection site nodules with weekly
  • •Pancreatitis risk

Always consult with a healthcare professional before starting any peptide therapy.