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Plecanatide
Performance & EnduranceGuanylate cyclase-C agonist for chronic constipation, similar to linaclotide.
Key Benefits
- ✓Relieves chronic constipation
- ✓Treats IBS-C
- ✓Increases intestinal fluid
- ✓Improves bowel regularity
- ✓Reduces straining
Dosing Information
Dosage Range
3 mg
Frequency
Once daily
Typical Duration
Ongoing
Detailed Protocol
Taken orally once daily with or without food. Can be taken at any time of day. Prescription medication.
About Plecanatide
Plecanatide (Trulance) is a synthetic 16-amino acid peptide structurally related to uroguanylin that activates guanylate cyclase-C receptors. It increases intestinal fluid and promotes bowel movements. FDA-approved for chronic idiopathic constipation and IBS-C.
Research Notes
FDA-approved in 2017. Clinical trials show efficacy in improving bowel movements and reducing symptoms in CIC and IBS-C.
Potential Side Effects
- •Diarrhea
- •Abdominal distension
- •Flatulence
- •Upper respiratory infection
Always consult with a healthcare professional before starting any peptide therapy.