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Dulaglutide

Metabolic & Weight Management

Long-acting GLP-1 receptor agonist for type 2 diabetes and weight management, marketed as Trulicity.

Key Benefits

  • ✓Improved blood sugar control
  • ✓Moderate weight loss (3-5 kg)
  • ✓Cardiovascular risk reduction
  • ✓Once-weekly convenience
  • ✓Reduced appetite
  • ✓Lower HbA1c

Dosing Information

Dosage Range
0.75-4.5 mg
Frequency
Once weekly
Typical Duration
Ongoing after titration

Detailed Protocol

Administered via subcutaneous injection once weekly using a pre-filled pen. Can be taken any day of the week, with or without food. Dose escalation over 8-12 weeks.

About Dulaglutide

Dulaglutide is a once-weekly GLP-1 receptor agonist consisting of two identical chains, each containing a GLP-1 analog covalently linked to a human IgG4-Fc heavy chain. This structure extends its half-life to about one week. FDA-approved for type 2 diabetes with proven cardiovascular benefits.

Research Notes

REWIND trial demonstrated cardiovascular benefits. Well-established safety profile with years of clinical use. User-friendly single-dose pen device.

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Potential Side Effects

  • •Nausea
  • •Diarrhea
  • •Abdominal pain
  • •Decreased appetite
  • •Vomiting
  • •Fatigue

Always consult with a healthcare professional before starting any peptide therapy.